Vaxcyte Senior Scientist, Analytical Development at Vaxcyte leads analytical method development for biologics and vaccine programs. This role drives method optimization, troubleshooting, and provides mentorship to junior team members.
Responsibilities
Provide technical leadership and strategic direction for method development, optimization and qualification/validation readiness
Define development strategies and experimental roadmaps, identify critical method attributes, set robustness/qualification approaches, and drive alignment with program and regulatory expectations
Lead complex troubleshooting and investigations across assays and instrumentation
Establish root-cause and preventive controls
Mentor others in problem-solving and technical approaches
Author, review, and maintain high-quality technical documentation including method protocols, development reports, qualification documentation, SOPs, and technical summaries
Qualification
PhDExcellent communication skillsAbility to lift up to 25 lbs
Required
PhD, MS or Bachelor’s degree in Chemistry, Biochemistry, Biology, Pharmaceutical Sciences, or a related scientific discipline. PhD with 5+ years; MS with 8+ years; BS with 10+ years of relevant industry experience in analytical development, QC, or related field. Other combinations of education and/or experience may be considered.
Extensive hands-on experience across a broad analytical technique, such as UV-Vis, HPLC, CE, SDS-PAGE, icIEF, Liquid chromatography, Mass Spectrometry, enzyme kinetics, colorimetric and fluorescent plate-based assays, ELISA, Western Blot, and PCR.
Experience leading method development or optimization activities preferred.
Deep expertise in analytical chemistry/biochemistry with broad understanding across platforms.
Recognized technical leader in troubleshooting complex, cross-cutting assay/instrument/system issues; drives investigations to root cause and establishes preventive controls.
Advanced capability in data analysis and interpretation, including method performance characterization, statistical evaluation, and automation/standardization of data workflows where appropriate.
Exemplary quality mindset and documentation rigor; authors/sets standards for methods, protocols, reports, and ensures audit/inspection readiness.
Demonstrated ability to lead multiple priorities and influence program direction; effectively resource-plans, remove blockers, and mentor others to deliver results.
Excellent communication skills: effectively communicate risk, options, and recommendations to stakeholders and leadership, and align cross-functional teams on path forward.
Ability to work in a laboratory environment for extended periods.
Ability to lift up to 25 lbs.
Use of personal protective equipment (PPE) required.
