Senior Associate Scientist I/II, Purification Sciences

San Diego HQfull time

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senior

$88k–$128k

H1B: no

Iambic Therapeutics The Senior Associate Scientist I/II, Purification Sciences at Iambic Therapeutics will perform chromatography-based purification to support small-molecule drug discovery. The role includes developing purification methods and maintaining chromatography instrumentation.

Responsibilities

Perform routine and moderately complex small-molecule purification using preparative LC and SFC, supporting medicinal chemistry and high-throughput chemistry workflows.
Develop and optimize purification methods, including column/mobile-phase selection, gradients, sample loading, and fraction collection.
Operate prep LC, prep SFC, analytical LC, and LC/MS systems and perform analytical QC of purified compounds.
Perform routine instrument maintenance and troubleshoot common chromatography, fluidics, hardware, and software issues.
Monitor instrument performance and proactively identify issues to maintain reliable laboratory operations and minimize downtime.
Support high-throughput and automated purification workflows, including sample submission, purification, fraction handling, compound recovery, and data reporting.
Work closely with medicinal chemists and other scientists to prioritize samples and deliver purified compounds with appropriate purity, recovery, and turnaround time.
Support evaluation and implementation of new purification methods, columns, instrumentation, and workflow improvements.
Maintain accurate experimental and instrument documentation and contribute to laboratory best practices.

Qualification

Strong attention to detailExperience with AgilentABOUT IAMBIC THERAPEUTICSIambic Therapeutics (NasdaqMISSION & VALUES

Required

B.S. or M.S. in Chemistry, Pharmaceutical Sciences, Chemical Engineering, or a related discipline with 3+ years of experience
Relevant hands-on laboratory experience in chromatography and small-molecule purification; level will be determined based on experience and demonstrated technical capabilities.
Working knowledge of chromatographic separation principles and method optimization.
Strong attention to detail, problem-solving skills, and ability to work effectively in a fast-paced, collaborative research environment.

Preferred

Experience with preparative LC and/or preparative SFC is strongly preferred; SFC experience is highly desirable.
Experience operating and troubleshooting chromatography instrumentation is strongly preferred.
Experience with LC/MS-based characterization and purity assessment is desirable.
Experience with automated or high-throughput laboratory workflows is desirable.
Experience with Agilent, Shimadzu, SCIEX, or comparable platforms is a plus.
ABOUT IAMBIC THERAPEUTICS
Iambic Therapeutics (Nasdaq: IAM) is a technology and clinical-stage life sciences company headquartered in San Diego. By utilizing molecular superintelligence — integrating proprietary AI with automated, scalable chemistry and biology experimentation — our platform is designed to address the totality of drug discovery and development. At Iambic, we are building an engine that is designed to power the future of medicine. Learn more at iambic.ai.
MISSION & VALUES

Benefits

Medical
401(k)
Life Insurance

Company

Iambic Therapeutics

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