Senior Scientist, Antibody Characterization

South San Francisco, CAfull timeOn Site

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senior

$136k–$170k

H1B: no

Xairatherapeutics Senior Scientist in Antibody Characterization responsible for hands-on laboratory work to support therapeutic molecule discovery. Characterizes antibodies using BLI and SPR biosensor platforms and performs developability assessments.

Responsibilities

As a part of the Protein Analytics team, you will play a crucial role in discovering and developing novel biotherapeutics. The ideal candidate will have extensive experience characterization of monoclonal and bi/multispecific antibodies within a biotherapeutics discovery setting, coupled with a proactive and can-do attitude. This is a hands-on, lab-based position.
Support the discovery and development of therapeutic molecules through hands-on laboratory work.
Characterize antibodies in high-throughput manner via biolayer interferometry (BLI) and surface plasmon resonance (SPR) based biosensor platforms to determine Yes/No binding, Kinetics and Affinity information.
Screen antibodies and other antibody-like molecules for off-target binding assessment via BVP ELISA or other poly-specificity/poly-reactivity assays.
Perform early developability assessment on antibody panels using SPR, DLS, DSF, SEC and ELISA platforms.
Support other workflows as needed, including fluorescence based binding assays and assay automation.
Analyze experimental data, curate results and reports, and present findings to cross-functional teams.
Maintain experimental records in an ELN.
Ensure compliance with laboratory safety protocols and contribute to lab organization and operations.

Qualification

Basic knowledge of protein productionStrong organizational

Required

PhD degree in a relevant discipline with 5+ years of industry experience or a BS/MS degree with 10+ years of industry experience in biophysics, biochemistry, structural biology, or a related discipline
Candidates with fewer years of experience are also encouraged to apply, and the leveling of the role can be adjusted if needed
Extensive experience in antibody screening including monoclonals, bispecific, and other antibody-like molecules.
Extensive hands-on experience with ELISA, BLI and SPR based platforms (Carterra, Biacore).
Basic knowledge of protein production, purification and characterization techniques (including affinity, ion exchange, HIC, DLS, DSF and SEC).
Proficiency in data analysis software (e.g., GraphPad Prism) and other statistical tools.
Proactive attitude with a self-starter mindset.
Strong organizational, communication, and interpersonal skills.
Strong collaborative skills and interest in working in cross-functional teams and a startup environment.
Excellent problem-solving and troubleshooting abilities.
Ability to work independently with accountability and meticulous attention to detail.